Car Rental - Fort Myers

 

Relax how you desire with car rental in Fort Myers and discover the gateway to an alluring stretch of islands along southwest Florida’s Gulf Coast. Sunbathe on the shelling beaches, enjoy a spot of backwater fishing, take in some waterfront entertainment or learn about the estates of renowned US historical figures who once called Fort Myers home.

Start your journey at the pick-up point in Southwest Florida International Airport – a half-hour drive from central Fort Myers – or at one of our Fort Myers car rental locations near Page Field.

Chase the sun in a stylish convertible, pack the family and their luggage into a spacious sedan or SUV, or prepare for a fun-filled road trip along the Florida coast in a sleek sports car. Whatever your plans, you’ll find something in our collection of rental cars at Fort Myers.

Arrange Fort Myers car rental and take off into the sunset for a laidback trip around southwest Florida.

Fort Myers Locations

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Map data ©2026 Google, INEGI
Map data ©2026 Google, INEGI

A Quick Guide to Fort Myers

Fort Myers Beach

Seven miles of white-sand coastline stretch out along Fort Myers Beach, making finding a peaceful spot easy. Look out for the shells washed ashore and walk along the pier for picturesque views.

Cayo Costa Beach

One of the largest Floridian barrier islands, Cayo Costa is perfect for peaceful activities such as shelling, fishing and camping. Mostly unspoiled, as it’s only accessible by boat, you might see a dolphin if you’re lucky.

Edison and Ford Winter Estates

Explore the minds and lives of two iconic Americans, Thomas Edison and Henry Ford, who built their neighboring winter escapes in Fort Myers. Choose a professional or self-guided tour of their historic homes, gardens and laboratory and admire exhibits including Edison’s 1916 Model T and phonograph.

Spring Training

Warmer weather attracts the likes of baseball’s Boston Red Sox and Minnesota Twins for a few training games every spring before the season starts. Usually taking place at Hammond Stadium (33912) in March, catch a game and immerse yourself in the relaxed, friendly atmosphere for a lot less than regular season games.

IMAG History and Science Center

Interactive exhibits bring science, history and nature to life in this incredible downtown museum that combines an aquarium, museum, cinema and garden into one. Travel back 150 years with the virtual reality experience of Fort Myers in the mid-19th century. Here, you can interact with sea creatures in the Touch Tank and improve your brain power with Mind Magic puzzles.

The Veranda

For more than 40 years, The Veranda has been impressing diners in downtown Fort Myers. Its leafy courtyard and early-20th century decor are matched only by an enticing menu, full of southern seafood and steak dishes.

Harold’s

South along Tamiami Trail sits Harold’s 30-seat restaurant. The farm to table approach means the menu changes weekly, depending on seasonality. Expect top-notch traditional American meals, with everything from the beet salad to delicious desserts made from scratch.

Blanc

Close to the Cypress Lake neighborhood lies this French-owned restaurant. Its small size, just 22 seats, contrasts with the big flavors on a menu packed with Florida favorites such as stone crab claws, prawns, cured salmon and Duroc pork chops.

Hotel Indigo

Stay in the buzzing riverfront commercial district at the heart of downtown. This boutique hotel, just two blocks from Centennial Park, has comfortable rooms and the added class of a rooftop pool. There’s a small daily fee for parking your Fort Myers rental car on-site, or you can choose to pay hourly at one of the nearby parking garages.

Pink Shell Beach Resort

The Pink Shell Beach Resort is a relaxed sanctuary along Fort Myers Beach. Aside from the studio, villa and condo rooms all with ocean views, a massive Octopool is the resort’s main highlight. It keeps adults and kids alike entertained, while there’s a tranquil Aquagene Spa too.

DiamondHead Beach Resort

At the north end of Fort Myers Beach, not far from Times Square, DiamondHead Beach Resort is a family-friendly resort overlooking the Gulf of Mexico. Relax with sunset ocean views, join in with organized activities such as arts and crafts or rent a kayak and get out on the water.

Driving In and Around Fort Myers

  • Short-term parking is available at Fort Myers Beach on Old San Carlos Boulevard, Estero Boulevard and Fifth Street (all 33931). You can find long-term parking for your rental car in Fort Myers at the lot under Matanzas Pass Bridge (33931).
  • Downtown Fort Myers is easy to park your car rental in, with many public parking lots, including a 24-hour garage at 2286 Main Street (33901). Spaces are also found at 1400-1498 Heitman Street (33901) near Centennial Park and 1300 Hendry Street (33901), by the waterfront.
  • On street and metered parking is available across Fort Myers, with charges varying depending on the time and neighborhood.

Fort Myers is connected to the wider Lee County, Florida state and its neighboring islands by a few key roads:

  • Route 75 passes through eastern Fort Myers, connecting it to Tampa in the north and Miami in Florida’s southeast.
  • Route 41, known as the Tamiami Trail, reaches Fort Myers from the north, crosses the Caloosahatchee River and heads south across to Miami – running almost parallel to Route 75.
  • San Carlos Boulevard (State Road 867 and 865) runs from downtown Fort Myers to San Carlos Island, Fort Myers Beach and Estero Island.

The morning commute in Fort Myers starts around 6:00AM, lasting until about 8:30AM. In the afternoon, between 3:00PM and 5:00PM are the peak hours, although rush hour can last until 7:00PM. If you’re exploring Fort Myers by rental car, you may want to plan around these times.

How to Get From Fort Myers to Orlando

The 160-mile trip to Orlando takes around three hours from Fort Myers by rental car. Head north on Route 41 before joining Route 17 and taking I-4 for the last 40 miles of the trip to reach Orlando.

 

How to Get From Fort Myers to Miami

Take Route 41 north and merge onto Route 75, staying on it for most of the 127-mile drive from Fort Myers to Tampa. Use exit 256 along Selmon Expressway and reach Tampa in around two hours.

 

How to Get From Car Rental in Fort Myers to Tampa

Head south down Route 75 from car rental in Fort Myers to Miami, passing through Big Cypress National Preserve, from Florida’s west to east coast to make the 157-mile journey in around three hours.