Car Rental - Winston-Salem

 

Rent a car in Winston-Salem to explore the Piedmont Triad region of North Carolina. Known as the ‘Twin City’, Winston-Salem offers the best of both worlds with its charming historic district and bustling Downtown.

Collect your rental car from one of our Hertz locations in the city for easy access to Old Salem, Winston-Salem State

University and Wake Forest University. Greensboro and High Point are just a short drive away too if you fancy exploring even more of Piedmont Triad.

Journey back in time at the Old Salem Museums and Gardens to learn about the original settlers. Visit the Reynolda Estate and Gardens to discover its American art collection spanning almost 300 years, then stop by one of the local restaurants for a true taste of the south.

With a wide range of sedans and SUVs to choose from, Hertz caters to every kind of business trip or car rental for a family vacation. Reserve your Winston-Salem car rental today.

Winston-Salem Locations

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Map data ©2026 Google
Map data ©2026 Google

A Quick Guide to Winston-Salem

Winston-Salem old salem

Old Salem Museums & Gardens

900 Old Salem Road, NC, 27101

Travel back in time to discover the history of the early south. A costumed guide will lead you through the town’s restored buildings such as Salem Tavern and the Single Brother’s House. Pick up some Moravian cookies from the Winkler Bakery, then head to the Museum of Early Southern Decorative Arts to learn more about the lives of the original settlers. There’s a visitor parking lot on-site, or street parking nearby for your Winston-Salem rental car.

Reynolda House Museum of American Art

Reynolda House Museum of American Art

2250 Reynolda Road, NC, 27106

Venture inside businessman R.J. Reynolds’ restored 1917 home to explore an impressive collection of American art which dates back to 1755. The museum features more than 300 paintings, photos and sculptures, including notable works by Gilbert Stuart, Mary Cassatt and Georgia O’Keefe. You’ll also find antiques, clothes and toys that perfectly capture the history of the house. Free parking is available for visitors so you can leave your Winston-Salem car rental in the lot while you explore.

Winston-Salem Tanglewood Park

Tanglewood Park

4061 Clemmons Road, NC, 27012

Just a short drive from Downtown, along the I-40, Tanglewood Park offers year-round activities for the whole family to enjoy. Here, you can go fishing and pedal boating on the lakes, have a swing on the Championship golf course or make a splash in the seasonal Aquatic Center. There are also walking trails, colorful gardens and multiple picnic areas. There are designated parking spots along the trails for you to leave your Winston-Salem rental car.

Winston-Salem Marriott

425 North Cherry Street, NC, 27101

Located in Downtown, this Marriott hotel is well-placed for exploring the local museums, stores and eateries, and offers direct access to the Benton Convention Center. Stylish rooms feature modern decor, plush furnishings and sleek bathrooms. Upgrade to M Club Level to enjoy the exclusive lounge with complimentary dining and business facilities. Treat yourself to valet parking, or leave your Winston-Salem rental car at the Cherry/Fifth Street parking deck just 0.1 miles away.

Kimpton Cardinal Hotel

401 North Main Street, NC, 27101

This historic hotel is notable for its original 1929 architecture that inspired the Empire State Building. Today, elegant rooms offer luxury touches like playful artwork, premium bedding and floor-to-ceiling windows. Settle down for sweet tea in the Art Deco lounge, dine at the brasserie or stop by the on-site leisure center for basketball and bowling. Choose valet parking with unlimited in/out privileges, or daily parking for up to four hours for your Winston-Salem rental car. Both will attract a small fee.

The Graylyn Estate

1900 Reynolda Road, NC, 27106

Just north of the city, the Graylyn Estate captivates guests with its old-world charm and quality amenities. You’ll find 85 cozy guest rooms, 15 meeting rooms and an international conference center on-site – ideal if you’re visiting Winston-Salem on business. You can also enjoy complimentary parking for your Winston-Salem rental car on-site.

Ryan’s Restaurant

719 Coliseum Drive, NC, 27106

Serving tender steaks and fresh seafood, Ryan’s Restaurant creates a snug setting for an upscale dining experience. Start with a signature appetizer like jumbo lump crab cakes or bacon-wrapped scallops, followed by one of the seasonal steak or fish entrees. Pick a table by the window for idyllic views of the surrounding oak trees and trickling stream.

Di Lisio’s Italian Restaurant

301 Brookstown Avenue, NC, 27101

Treat yourself to a taste of Naples at Di Lisio’s in Downtown. This family-owned restaurant showcases authentic Italian dishes, including toasted bruschetta, homemade lasagna and ricotta-stuffed ravioli. Save room for dessert – classics such as cannoli and tiramisu are not to be missed.

Milner’s American Southern

630 South Stratford Road, NC, 27103

Indulge in a southern-inspired brunch and dinner menu, lined with local ingredients and regional flavors. Start your morning with crème brûlée French toast and applewood bacon, or enjoy a romantic dinner of sirloin steak, roasted fingerling potatoes and house sauce.

Driving In and Around Winston-Salem

 

  • Sixth-Cherry Parking Deck (27101) offers hourly and monthly spaces opposite the Benton Convention Center, with all-day parking available on weekends.
  • Fourth Street Parking Deck (27101) is open 24/7, with more than 800 spaces close to the Stevens Center and Downtown’s popular cafes and restaurants.
  • You’ll find 800 metered on-street parking spaces in downtown Winston-Salem. These spaces are free on weekends, and on weekdays after 5pm.

 

 

  • Interstate 40 (I-40) connects Winston-Salem to Asheville in the west and Greensboro and Raleigh in the east.
  • US Route 52 (US 52) is a north to south highway that merges with the I-285 and I-85 between Winston-Salem and Charlotte.
  •  US Route 421 (US 421) runs east to west through the heart of Winston-Salem and across the Tennessee border. In the east, it overlaps with I-40 towards Greensboro and Wilmington.

 

How to Get From Winston-Salem Car Rental to High Point

It takes around 25 minutes to drive the 20 miles from Winston-Salem car rental to High Point:

  1. Leaving Downtown, head north on Main Street.
  2. Turn right on to North Martin Luther King Jr Drive.
  3. Take a right again to follow the slip road on to US 52 South.
  4. Merge on to US 52, then take Exit 107A towards I-40 East.
  5. Continue along I-40 E for around 11 miles.
  6. Take Exit 65 on to North Main Street to arrive in High Point.

 

How to Get From Car Rental at Winston-Salem to Greensboro

Greensboro is around a 30-minute drive from car rental in Winston-Salem. Just head east along the US 421 South and take Exit 208 to merge with the I-40 East. Follow I-40 E for 11 miles, then take Exit 218B on to Freeman Mill Road to reach downtown Greensboro.

 

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