Santa Maria Novella Railway Station is one of Italy's busiest railway stations, and the gateway into the city for almost 60 million people a year. If you hire a car at the nearby Via Borgo Ognissanti, you'll find yourself close to the north bank of the River Arno, handily placed to explore the city centre a few blocks to the east. It's easy to escape Florence too: the SS67 ring road is just a few blocks to the west.