The Mitte district of Berlin is right in the heart of the city. If you pick up a hire car here you’ll soon find the area includes many of the major sights of the German capital. The Mitte region stands alongside the Spree waterway but the road connections with other parts of the city are good. Look out for the major Friedrichstrasse Street running north to south through the district - it is lined with major shops and cultural venues and passes through what used to be called ‘Check-Point Charlie’ between the old West and East Berlin.